0216 : Involvement of the receptor-type tyrosine-protein phosphatase F gene PTPRF, a cell adhesion-like molecule, in Mitral Valve Prolapse (MVP)
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چکیده
منابع مشابه
Receptor-like protein-tyrosine phosphatase α enhances cell surface expression of neural adhesion molecule NB-3.
Neural adhesion molecule NB-3 plays an important role in the apical dendrite development of layer V pyramidal neurons in the visual cortex, and receptor-like protein-tyrosine phosphatase α (PTPα) mediates NB-3 signaling in this process. Here we investigated the role of PTPα in regulating cell surface expression of NB-3. We found that cortical neurons from PTPα knock-out mice exhibited a lower l...
متن کاملFloppy mitral valve (FMV)/mitral valve prolapse (MVP) and the FMV/MVP syndrome: pathophysiologic mechanisms and pathogenesis of symptoms.
Mitral valve prolapse (MVP) results from the systolic movement of a portion or segments of the mitral valve leaflets into the left atrium during left ventricular systole. It is well appreciated today that floppy mitral valve (FMV) is the central issue in the MVP and mitral valve regurgitation (MVR) story. The term FMV refers to the expansion of the area of the mitral valve leaflets with elongat...
متن کاملUCSD MOLECULE PAGES Tyrosine-protein phosphatase non-receptor type 2
TC-PTP is a ubiquitous non-receptor type protein tyrosine phosphatase that shows highest expression in hematopoietic tissues. It regulates many signal transduction pathways in hematopoietic as well as non-hematopoietic cells. TCPTP has two splice variants, an endoplasmic reticulum-localized TC48, and predominantly nuclear TC45. Upon various stress conditions and insulin stimuli, TC45 comes out ...
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Marcus-gunn phenomenon is a congenital and sometimes hereditary anomaly, in which a ptotic eyelid retracts momentarily when the mouth is open, or the jaw is moved. These associated movements attributed to abnormal connections between the central mechanisms innervating the pterygoid and elevator muscles. Sometimes this anomaly is associated with dual,s retraction syndrome, duplex kindneys and ur...
متن کاملE VALUATION OF ADENYLATE CYCLASE ACTIVITY IN MITRAL VALVE PROLAPSE
The term mitral valve prolapse (MVP) is used for a particular subset of patients with hyperadrenergic dysautonomia. It occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. The adenylate cyclase activity in MVP dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 norma...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2016
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(16)30514-6